A CAD System for the Acquisition and Classification of Breast TMA in Pathology

Breast cancer is the most common type of cancer and the fifth leading cause of death in women over 40. Therefore, prompt diagnostic and treatment is essential. In this work a TMA Computer Aided Diagnosis (CAD) system has been implemented to provide support to pathologists in their daily work. For that purpose, the tool covers each and every process from the TMA core image acquisition to their individual classification. The first process includes: tissue core location, segmentation and rigid registration of digital microscopic images acquired at different magnifications (5x, 10x, 20x, 20x and 40x) from different devices. The classification process allows performing the core classification selecting different types of color models, texture descriptors and classifiers. Finally, the cores are classified into three categories: malignant, doubtful and benign.